Pasquale
solo_traveller · Aug 2026
“Great place and the restaurant and staff were great!!”
Everything
Nothing
← Rome hotels
Very Good
5,041 reviews
8.3
★★★★★
Twentyone Hotel
1 / 30
About this hotel
What guests liked
Great locationHelpful staffClean rooms
Could be better
Small roomsLimited breakfast optionsVarying room quality
Modern Boutique Hotel on Rome's Best Shopping Street
The Twentyone Hotel offers a sleek stay on Via Cola di Rienzo, a prime shopping destination in Rome. Just a short stroll away from iconic landmarks like Castel Sant'Angelo and the historic center, this modern boutique hotel is the perfect blend of style and convenience.
Ultra-Modern Rooms and Dining Experience
Experience luxury in every detail with ultra-modern rooms boasting minimalist decor and top-notch amenities including LCD satellite TV, air conditioning, minibar, and complimentary WiFi. Indulge in a delightful culinary journey at the on-site restaurant offering traditional Roman and classic Italian dishes paired with a wide selection of wines and champagne.
Prime Location in Elegant Prati District
Located in the upscale Prati district, the hotel is a stone's throw away from the Vatican and Saint Peter's Basilica, making it an ideal choice for travelers interested in exploring the city's rich history. With easy access to Lepanto Metro Station and bus links to Roma Termini Train Station, your Roman adventure begins at the doorstep of Twentyone Hotel.
Book your stay now and elevate your Roman holiday experience at Twentyone Hotel.
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Facilities
WiFi available
Free WiFi
Parking
Non-smoking rooms
Air conditioning
Fitness center
24-hour front desk
Restaurant
Room service